medical research pdf

-226.156 -13.2 Td ͂fŽIL‡fDÓÐh*š‚&£Ih"š€ÆFn6Ll{ÛÌpÑÿ÷ŵ -224.112 -13.2 Td [(r)-5(e)-2.64432(c)-2.64432(o)-7.00166(r)-5.00129(d)-7.00166(s)2.71284( )-15.5719(i)0.356603(n)5.06981(t)0.356603(o)-7.00166( )-15.5719(a)-2.64432( )-15.5719(u)5.07055(s)2.71284(a)-2.64432(b)-7.00166(l)0.35513(e)-2.64358( )-15.5727(d)-7(a)-2.64358(t)0.356603(a)-2.64358(b)-7(a)-2.64358(s)2.71284(e)-2.64358( )-15.5727(f)7.07165(o)-7(r)-5.00129( )-27.6441(m)17.4971(e)-2.64358(d)-7(i)0.356603(c)-2.64358(a)-2.64358(l)0.356603( )-15.5727(r)-5.00129(e)-2.64358(s)2.71284(e)-2.64358(a)-2.64358(r)-5.00129(c)-2.64358(h)]TJ The research programme comprised: 1. [(t)0.356235(e)-2.64432(n)5.06981(t)0.356235(i)0.356603(a)-2.64432(l)-11.7149( )-184.572(b)-7.00166(e)-2.64432(n)5.06981(e)-14.7158(f)7.07018(i)0.356603(t)0.356603(s)-9.35863( )-184.572(f)7.07018(r)-5.00129(o)-19.0731(m)5.42568( )-184.573(r)-5.00129(e)-2.64358(s)2.71284(e)-2.64358(a)-2.64358(r)-5.00129(c)-14.715(h)-7(. 235.173 0 Td 232.408 0 Td [(. [(b)-7.00166(r)-5(a)-2.64432(r)-5(y)17.1413( )-51.7863(o)-19.0731(f)7.07018( )-51.7863(M)-4.28808(e)-2.64432(d)-7.00166(i)0.356603(c)-2.64432(i)-11.7141(n)5.06981(e)-2.64495( )-51.7863(\()-5.00129(N)-14.3599(L)7.42678(M)-4.28808(\))-5.00103(,)-3.5012( )-51.7871(a)-2.64358(n)-7( )-51.7871(o)-7(r)-5.00129(g)5.07055(a)-2.64358(n)5.07055(i)0.356603(z)-2.64358(a)-2.64358(t)0.356603(i)0.356603(o)-19.0724(n)5.07055( )-63.8585(w)9.78302(i)-11.7149(t)0.356603(h)5.07055(i)-11.7149(n)5.06907( )-63.8585(N)-2.28698(I)-5.00129(H)]TJ [(p)-7.00166(l)0.356235(a)-2.64432(n)5.06981(n)5.06981(e)-2.64432(d)-7.00166( )-184.572(b)-7.00166(u)5.06981(d)-19.0731(g)5.06981(e)-2.64432(t)0.35734( )-196.644(f)7.07018(o)-7.00166(r)-5.00129( )-184.573(2)-7(0)-7(1)-7(0)-7.00154(-)7.07018(2)-7(0)-7(1)5.07055(1)-7(,)-3.5012( )-184.573(t)0.356603(h)5.07055(e)-2.64421( )-184.573(p)-7(e)-2.64358(r)-5.00129(i)0.356603(o)-7(d)-7( )-184.573(a)-2.64358(t)0.356603( )-184.573(t)0.356603(h)5.07055(e)-2.64358( )-184.573(e)-14.715(n)5.06907(d)]TJ [(p)-7.00239(a)-2.64358(r)-5.00129(t)0.356603(n)5.06907(e)-2.64358(r)-5.00129(s)2.71431(h)5.06907(i)0.356603(p)-7.00239(s)2.71431(,)-3.5012( )-112.144(s)-9.35715(u)5.06907(c)-14.715(h)5.06907( )-112.144(a)-2.64358(s)2.71431( )-112.144(t)0.356603(h)5.06907(e)-2.64358( )-112.144(c)-2.64358(o)-7.00239(l)0.356603(l)-11.7149(a)-2.64358(b)-7.00239(o)-7.00239(r)-5.00129(a)-2.64358(t)0.356603(i)0.356603(o)-7.00239(n)5.06907( )-112.144(s)2.71431(e)-2.64358(e)-2.64358(n)5.06907( )-112.144(b)-7.00239(e)-2.64653(t)-11.7178(w)21.856(e)-2.64653(e)]TJ 173.855 0 Td /R8 8.04 Tf 0000000015 00000 n )-3.50077( )-51.7871(B)-9.00202(o)-7.00239(t)]TJ 216.537 0 Td 223.15 0 Td [(i)-2.53165(n)-0.949354( )-0.474532(M)-2.68942(e)-1.84432(d)-0.949064(i)-2.53165(c)3.16518(a)-1.84432(l)-2.53165( )4.53496(R)0.737359(e)-1.84432(s)-1.74036(e)-1.84432(a)-1.84432(r)-2.63561(c)-1.84432(h)4.06014( )]TJ [(t)-6.12624(m)0.379683(. -235.895 -13.2 Td )-3.5012( )-100.073(B)-9(u)5.06907(t)-11.7178( )250]TJ [(s)2.71321(u)5.06981(p)-7.00166(p)-7.00166(o)-7.00166(r)-5.00129(t)0.356603(i)0.356603(n)-7.00166(g)5.06981( )-100.072(t)0.356603(h)5.06981(e)-2.64432( )-112.143(i)0.356603(n)-7.00166(f)7.07018(o)-7.00239(r)-17.0728(m)17.4971(a)-2.64358(t)-11.7149(i)0.356603(o)-7(n)5.07055( )-100.073(s)-9.35863(y)-7(s)2.71431(t)0.356603(e)-14.715(m)5.42568(s)2.71284( )-100.073(a)-14.715(n)5.07055(d)-7( )-100.073(s)2.71284(o)-7(f)7.07018(t)-23.7863(w)9.78302(a)-2.64358(r)-5.00129(e)-2.64358( )-100.073(a)-2.64358(p)-7.00239(p)]TJ -229.522 -13.2 Td [(l)0.356603(a)-2.64358(n)5.06907(c)-2.64358(e)-2.64358( )-257.002(s)-9.35715(y)5.06907(s)2.71431(t)0.356603(e)-14.715(m)5.42568( )-269.073(f)7.07018(o)-7.00239(r)-5.00129( )-257.002(c)-2.64358(o)-19.0739(m)5.42568(m)5.42568(u)-7.00239(n)5.06907(i)0.356603(c)-2.64358(a)-14.715(b)-7.00239(l)0.356603(e)-2.64358( )-257.002(d)-7.00239(i)0.356603(s)2.71431(e)-2.64358(a)-2.64358(s)2.71431(e)-2.64358( )-257.002(s)2.71136(u)5.06907(r)-17.0698(v)5.06907(e)-2.64653(i)0.353656(l)0.353656(l)0.353656(a)-14.718(n)5.06907(c)-2.64653(e)-2.64653(,)]TJ -217.379 -13.2 Td )-3.50077( )-75.93(M)-4.28808(o)-7.00239(r)-5.00129(e)-2.64358(o)-7.00239(v)5.06907(e)-2.64358(r)-5.00129(,)-3.5012( )-63.8585(a)-2.64358(s)2.71431( )-88.0014(w)21.856(e)-2.64358( )-75.93(e)-2.64358(n)5.06907(t)0.356603(e)-2.64358(r)-5.00129( )-75.93(a)-2.64358(n)5.06907( )-75.93(i)-11.7178(n)5.06907(c)-2.64653(r)-4.99834(e)-2.64653(a)-2.64653(s)2.71136(i)]TJ [(T)-0.158381(h)-0.949064(e)-1.84493( )-0.474532(R)0.737482(o)-0.949064(l)-2.53165(e)-1.84493( )-0.474532(o)-0.949064(f)2.37327( )-0.474532(I)-2.63561(n)-0.949064(f)2.37388(o)-0.949064(r)-2.63561(m)6.53827(a)-1.84432(t)-2.53165(i)-2.53165(o)-0.949064(n)-0.949064( )-0.474532(T)-0.156547(e)-1.84432(c)-1.84432(h)-0.949064(n)-0.949064(o)-0.949064(l)-2.53165(o)-0.949064(g)-0.949064(y)-0.949064( )4.53359( )]TJ endobj [(m)5.42641(a)-2.64432(t)-11.7152(h)5.06981(e)-14.7158(m)17.4979(a)-14.7158(t)0.356603(i)0.356603(c)-2.64432(a)-2.64432(l)0.356603( )-172.501(s)2.71357(i)-11.7149(m)5.42641(u)-7.00166(l)0.35513(a)-2.64358(t)0.356603(i)0.356603(o)-7(n)-7(s)2.71284( )-172.502(t)0.356603(o)-7( )-172.502(p)-7(r)-5.00129(e)-2.64358(d)-7(i)0.356603(c)-2.64358(t)0.356603( )-172.502(h)5.07055(o)-7(w)21.8545( )-172.502(c)-2.64358(o)-19.0724(m)17.4971(p)-7(l)0.356603(e)-14.718(x)5.06907( )-172.502(b)-7.00239(i)0.356603(o)]TJ [(y)17.1405(,)-15.5727( )-75.93(f)7.07312(o)-7.00239(r)-4.99834( )-75.93(e)-14.718(x)5.06907(-)333.003]TJ [(f)7.07018(o)-7.00239(r)-17.0728(m)17.4971(a)-2.64358(t)0.356603(i)0.356603(c)-14.715(s)2.71431( )-88.0014(r)-5.00129(e)-2.64358(s)2.71431(e)-2.64358(a)-2.64358(r)-5.00129(c)-2.64358(h)5.06907( )-88.0014(h)5.06907(a)-14.715(s)2.71431( )-88.0014(c)-2.64358(o)-19.0739(m)17.4971(e)-2.64358( )-88.0014(p)-7.00239(r)-5.00129(i)0.356603(n)5.06907(c)-2.64358(i)0.356603(p)-7.00239(a)-2.64358(l)0.356603(l)-11.7149(y)17.1405( )-88.0014(t)0.356603(h)5.06907(r)-4.99834(o)-19.0739(u)5.06907(g)-7.00239(h)5.06907( )-88.001(t)0.353656(h)5.06907(e)]TJ 10.0995 -13.2 Td T*[([)-10.9459(4)6.51233(])4.00825( )-4.22092(K)19.1546(. [(r)-4.99834(t)0.353656( )-341.502(f)-4.99834(o)-7.00239(r)7.07312( )250]TJ 202.831 0 Td 215.095 0 Td 221.948 0 Td [(d)-7.00239(i)0.356603(t)0.356603(i)0.356603(o)-7.00239(n)5.06907(,)-3.5012( )-75.93(e)-2.64358(f)-5.00129(f)7.07018(o)-7.00239(r)-5.00129(t)0.356603(s)2.71431( )-88.0014(f)7.07018(r)-5.00129(o)-19.0739(m)5.42568( )-75.93(c)-2.64358(a)-2.64358(B)-9(I)-5.00129(G)-2.28698( )-75.93(i)0.356603(n)5.06907(c)-14.715(l)0.356603(u)5.06907(d)-7.00239(e)-2.64358( )-75.93(d)-7.00239(e)-2.64358(v)5.06907(e)-2.64358(l)0.356603(o)-7.00239(p)-7.00239(i)0.353656(n)-7.00239(g)5.06907( )-88.0014(s)2.71136(o)-7.00239(f)7.07312(t)-23.7893(w)]TJ [(n)5.06907(d)-7.00239(i)0.356603(n)-7.00239(g)5.06907( )-88.0014(f)7.07018(o)-7.00239(r)-5.00129( )250]TJ 198.382 0 Td [(c)-2.64358(o)-7.00239(t)0.356603(l)0.356603(a)-14.715(n)5.07202(d)-7.00239( )250]TJ 23.16 TL 171.57 0 Td [(e)-2.64358( )-220.788(p)-7.00239(a)-2.64358(s)2.71431(t)-11.7149( )-220.785(5)5.06907( )250]TJ [(H)4.20038(e)10.3285(a)-4.62572(l)8.82427(t)-6.12989(h)-8.44093( )-4.22046(C)-5.93822(h)-8.44093(o)21.4674(i)-6.12989(c)-4.62572(e)10.3285(s)0.189848( )-4.22046(A)19.1527(c)-4.62572(t)-6.12989( )-4.22046(o)6.51324(f)4.00871( )250]TJ )-3.50077( )-88.0014(M)-4.28808(e)-2.64358(d)-7.00239(i)0.356603(c)-2.64653(a)-2.64653(l)0.353656( )-88.0014(r)-4.99834(e)-2.64653(s)]TJ 238.059 0 Td <> 208.362 0 Td [(i)0.356603(n)5.06907(g)5.06907( )-3.5012(t)0.356603(e)-2.64358(r)-5.00129(a)-2.64358(b)-19.0739(y)5.06907(t)0.356603(e)-2.64358(s)2.71431( )-3.5012(o)-7.00239(f)7.07018( )-3.5012(d)-7.00239(a)-2.64358(t)0.356603(a)-2.64358( )-15.5727(f)7.07018(o)-7.00239(r)-5.00129( )-3.5012(t)0.356603(h)5.06907(e)-2.64358(i)0.356603(r)-5.00129( )-3.5012(a)-2.64358(n)5.06907(a)-2.64358(l)-11.7149(y)5.06907(s)2.71431(i)0.356603(s)2.71431(. -231.206 -13.2 Td -232.769 -13.2 Td 209.324 0 Td 0000545984 00000 n 223.872 0 Td -211.608 -13.2 Td [(m)5.42568(a)-2.64358(t)0.356603(i)0.356603(o)-7.00239(n)5.06907( )-88.0014(c)-2.64358(a)-14.715(n)5.06907( )-88.0014(b)-7.00239(e)-2.64358( )-88.0014(e)-2.64358(x)5.06907(c)-2.64358(h)5.06907(a)-2.64358(n)-7.00239(g)5.06907(e)-2.64358(d)-7.00239(,)-3.5012( )-88.0014(i)0.356603(n)5.06907(t)-11.7149(e)-2.64358(g)5.06907(r)-5.00129(a)-2.64358(t)0.356603(e)-2.64358(d)-7.00239(,)-3.5012( )-88.0014(a)-2.64358(n)5.06907(d)-7.00239( )-88.0014(a)-2.64653(c)-2.64653(t)0.353656(e)-2.64653(d)5.06907( )-88.0014(u)5.06907(p)-7.00154(o)-7.00239(n)]TJ endobj Q [(i)0.356603(l)0.356603( )-208.716(o)-7.00239(f)7.07018( )250]TJ [(r)-5(e)-2.64432(p)-7.00166(o)-7.00166(r)-5.00129(t)0.356603( )-184.572(p)-7.00166(u)5.06981(b)-7.00166(l)0.356603(i)0.356603(s)2.71284(h)5.06981(e)-2.64358(d)-7.00166( )-196.644(b)-19.0731(y)17.1405( )-196.645(S)0.713207(i)0.356603(r)-5.00129( )-196.645(D)-2.28845(a)-2.64358(v)5.07055(i)-11.7149(d)-7( )-196.645(C)3.06944(o)-7(o)-7(k)5.07055(s)2.71284(e)-14.715(y)17.142(,)-3.5012( )-196.646(t)0.356603(h)5.07055(e)-2.64358( )-196.645(B)-9.00202(r)-5.00129(i)0.356603(t)0.356603(i)0.356603(s)-9.35715(h)5.06907( )]TJ -230.725 -13.2 Td 26 0 obj This is a quality controlled, peer-reviewed, open access INTERNATIONAL journal. 10.0995 -13.2 Td 228.44 0 Td 207.039 0 Td -219.423 -23.28 Td Q 223.15 0 Td [(r)-4.99834( )-15.5727(H)-2.28698(e)-2.64653(a)-2.64653(l)0.353656(t)0.353656(h)-7.00239( )250]TJ -76.1042 -31.8 Td [(\()-5.00129(N)-2.28698(I)-5.00129(H)-2.28698(\))-5.00103(,)-3.5012( )-160.43(a)-2.64358(l)0.356603(t)0.356603(h)5.06907(o)-7.00239(u)5.06907(g)-7.00239(h)5.06907( )-160.43(a)-2.64358(d)-7.00239(d)-7.00239(i)0.356603(t)0.356603(i)0.356603(o)-7.00239(n)5.06907(a)-2.64358(l)0.356603( )-160.43(f)-5.00129(u)-7.00239(n)5.06907(d)-7.00239(s)2.71431( )-160.43(c)-2.64358(o)-19.0739(m)17.4971(e)-2.64358( )-160.43(f)7.07018(r)-5.00129(o)-19.0739(m)17.5001( )-160.43(t)-11.7178(h)5.06907(e)-2.64653( )-160.43(C)3.07091(e)-14.718(n)5.06907(t)]TJ T*[(h)-8.44093(t)8.82427(t)-6.12989(p)-8.44093(:)8.82427(/)8.82427(/)-6.12989(w)4.19856(w)4.19856(w)19.1527(.)-4.22046(n)-8.44093(i)-6.12989(h)-8.44093(r)18.9629(.)-4.22046(a)-4.62572(c)10.3285(. [(D)3.23309(a)-2.50724(n)-0.957164(i)-5.15007(e)8.38316(l)-5.15007( )-0.478582(C)2.68538(a)-2.50724(s)7.83545(t)-5.15007(r)-4.60236(o)9.93323( )]TJ [(,)-3.5012( )-88.0014(t)0.353656(h)5.06907(e)-14.718( )250]TJ [(i)0.353656(c)-2.64653( )-27.6441(p)-7.00239(u)5.06907(b)-7.00239(l)-11.7178(i)0.353656(c)-2.64653(-)]TJ [(c)-2.64432(o)-7.00166(m)17.4979(b)-7.00166(i)-11.7149(n)5.06981(e)-2.64432(d)-7.00166( )-196.644(a)-14.7158(m)17.4979(o)-19.0731(u)5.07055(n)5.06981(t)0.356603( )-208.716(f)7.07044(r)-5.00129(o)-19.0724(m)17.4971( )-196.644(t)-23.7863(w)21.8545(o)-7( )-208.716(o)-7(f)7.07044( )-196.645(t)0.356603(h)5.07055(e)-2.64358( )-196.644(r)-5.00129(e)-2.64358(s)2.71284(e)-2.64358(a)-2.64358(r)-5.00129(c)-14.715(h)5.07055( )-196.645(c)-2.64358(o)-7(u)5.06907(n)5.06907(c)-14.715(i)0.356603(l)0.356603(s)2.71431( )-196.645(\()]TJ -215.816 -13.2 Td )-3.50077( )-100.072(T)-16.7162(o)-7.00166(d)-7.00166(a)-2.64432(y)17.1413(,)-3.50046( )-112.144(i)0.356301(n)-7.00166(f)7.07018(o)-7(r)-17.0728(m)17.4971(a)-2.64358(t)-11.7149(i)0.356603(c)-2.64358(s)2.71284( )-100.073(i)-11.7149(s)-9.35863( )-100.072(b)-7(e)-2.64358(i)0.356603(n)5.07055(g)-7( )-100.072(a)-2.64358(p)-7(p)-7(l)0.356603(i)0.356603(e)-2.64358(d)-7( )-100.073(a)-2.64358(t)0.356603( )-100.072(e)-2.64358(v)5.06907(e)-2.64358(r)]TJ 214.974 0 Td Q 0000189032 00000 n -211.127 -13.2 Td )-3.50077( )-160.43(A)9.78449(l)0.356603(t)-11.7149(h)5.06907(o)-7.00239(u)-7.00239(g)-7.00239(h)5.06907( )-160.43(t)0.356603(h)5.06907(e)-2.64358( )-160.43(d)-7.00239(i)0.356603(s)2.71431(t)0.356603(i)0.356603(n)-7.00239(c)-2.64358(t)0.356603(i)0.356603(o)-7.00239(n)5.06907( )-160.43(i)0.356603(s)2.71431( )-160.43(n)5.06907(o)-7.00239(t)0.356603( )-160.43(a)-2.64358(l)-11.7178(w)21.856(a)-14.718(y)5.06907(s)2.71136( )-160.43(p)-7.00239(e)]TJ q [(l)0.353656(a)-2.64653(t)0.353656(o)-7.00239(r)-17.0698(y)17.1405( )-75.93(a)-2.64653(n)5.06907(d)-7.00239( )250]TJ -207.4 -13.2 Td 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)-4.22046(H)4.20038(e)10.3285(a)-4.62572(l)8.82427(t)-6.12989(h)-8.44093( )-4.22046(A)19.1527(f)4.00871(f)4.00871(a)-4.62572(i)-6.12989(r)4.00871(s)0.189848(,)-4.22046( )10.7337(2)-8.44093(6)6.51324(,)10.7337( )250]TJ [(m)17.5001(e)-2.64653(d)-7.00239(i)0.353656(c)-14.718(a)-2.64653(l)0.353656( )250]TJ [(H)4.19856(u)-8.44093(m)0.383347(a)10.3285(n)-8.44093( )-4.22046(S)2.69438(e)10.3285(r)4.00871(v)6.51324(i)-6.12989(c)-4.62572(e)10.3285(s)0.189842( )-4.22046(\()4.00871(2)6.51324(0)-8.44093(0)6.51324(6)-8.44093(\))4.00871(,)-4.22046( )10.7337(h)6.51324(t)-6.12989(t)8.82427(p)-8.44093(:)8.82427(/)-6.12989(/)-6.12989(w)19.1527(w)4.19856(w)19.1527(.)-4.22046(n)-8.44093(l)8.82427(m)0.383347(.)-4.22046(n)-8.44093(i)8.82427(h)-8.44093(. 0.998087 0 0 1 275.52 414.12 Tm [(i)0.356603(n)5.06907( )-148.359(r)-5.00129(e)-2.64358(a)-2.64358(l)0.356301(-)7.07018(t)-11.7149(i)-11.7149(m)17.4971(e)-2.64358(,)-3.5012( )-148.359(a)-14.715(n)5.06907(d)-7.00239( 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)-63.8585(t)0.356603(h)5.06907(e)-2.64358( )-63.8585(l)0.356603(a)-2.64358(r)-17.0728(g)5.07202(e)-14.715( )250]TJ [(p)8.27446(o)5.71091(s)1.5851(i)-2.54398(t)-0.978454(i)-15.9031(o)-7.64825(n)8.27446(e)-10.2118(d)8.27446( )250.002]TJ )-4.22046(h)]TJ [(W)-9.64597(e)-2.64358(l)0.356603(l)0.356603(c)-2.64358(o)-7.00239(m)17.4971(e)-2.64358( )-75.93(T)-16.7162(r)-5.00129(u)5.06907(s)2.71431(t)0.356603(,)-3.5012( )-75.93(B)-9(B)-9(S)0.713207(R)3.07091(C)3.07091(,)-3.5012( )-75.93(a)-2.64358(n)-7.00239(d)-7.00239( )-75.93(C)3.07091(a)-2.64358(n)5.06907(c)-2.64358(e)-2.64358(r)-5.00129( )-75.93(R)3.07091(e)-2.64358(s)2.71431(e)-2.64653(a)-2.64653(r)-4.99834(c)-2.64653(h)5.06907( )-75.93(U)-2.28698(K)-2.28698( )-75.93(h)5.06907(a)-14.718(v)5.06907(e)-2.64653( )]TJ -221.347 -13.2 Td -249.12 -13.32 Td 4.16667 0 0 4.16667 0 0 cm BT ( )Tj )-3.5012(7)-7( )-3.5012(b)-7(i)0.356603(l)0.356603(l)0.356603(i)0.356603(o)-7(n)5.07055(. -209.564 -13.2 Td 211.488 0 Td [(s)2.71431(t)0.356603(a)-2.64358(k)5.06907(e)-14.715(h)5.06907(o)-7.00239(l)0.356603(d)-7.00239(e)-2.64358(r)-5.00129( )-112.144(e)-2.64358(n)5.06907(g)5.06907(a)-14.715(g)5.06907(e)-14.715(m)5.42568(e)-2.64358(n)5.06907(t)0.356603( )-124.216(n)5.06907(e)-2.64358(e)-2.64358(d)-7.00239(e)-2.64358(d)-7.00239( )-112.144(t)0.356603(o)-7.00239( )-112.144(i)0.356603(m)17.4971(p)-7.00239(r)-5.00129(o)-7.00239(v)5.06907(e)-2.64653( )-112.144(t)0.353656(h)5.06907(e)-2.64653( )-112.144(U)-2.28698(K)-14.3584(�)7.07312(s)2.71136( )-112.144(c)]TJ -210.406 -13.2 Td -219.303 -13.32 Td [(h)5.06907(a)-2.64358(s)2.71431( )-112.144(l)0.356603(e)-2.64421(d)-7.00239( )-112.144(t)0.356603(o)-7.00239( )-112.144(t)-11.7149(h)5.06907(e)-2.64358( )-112.144(d)-7.00239(e)-14.715(v)5.06907(e)-2.64358(l)0.356603(o)-7.00239(p)-19.0739(m)17.4971(e)-14.715(n)5.06907(t)0.356603( )-112.144(o)-19.0739(f)7.07018( )-112.144(t)-11.7149(h)5.06907(e)-2.64358( )-112.144(B)-9(I)-5.00129(G)-2.28698( 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)-4.22046(�)10.3285(U)4.19856(K)19.1527( )-4.22046(B)-5.9364(i)-6.12989(o)6.51324(b)-8.44093(a)10.3285(n)6.51324(k)-8.44093(:)8.82427( )-19.1746(I)33.917(n)-8.44093(f)4.00871(o)6.51324(r)4.00871(m)0.383347(a)-4.62572(t)-6.12989(i)-6.12989(o)6.51324(n)-8.44093( )-4.22046(L)27.7872(e)10.3285(a)-4.62572(f)4.00871(l)-6.12989(e)10.3285(t)-6.12989(�)-4.62572( )-4.22046(U)4.19856(K)19.1527( )-4.22046(B)-5.9364(i)-6.12989(o)6.51324(b)-8.44093(a)10.3285(n)6.51324(k)-8.44093( )-4.22046(\()]TJ 227.599 0 Td )-15.5722( )]TJ [(i)-11.7178(o)-7.00239(n)5.06907( )250]TJ -219.663 -13.2 Td -217.379 -13.2 Td 231.927 0 Td [(v)5.06907(i)-11.7149(n)-7.00239(g)5.06907( )-160.43(d)-7.00239(a)-2.64358(t)0.356603(a)-2.64358( )250]TJ )-3.50046( )-172.501(S)-11.359(y)5.06981(s)2.71284(t)0.356603(e)-14.715(m)5.42568(s)2.71284( )-172.502(b)-7(i)0.356603(o)-7(l)0.356603(o)-19.0724(g)-7(y)17.1414( )-172.502(u)-7(s)2.71284(e)-2.64358(s)2.71284( )-172.502(c)-2.64358(o)-19.0724(m)17.4971(p)-19.0724(u)5.07055(t)0.356603(e)-2.64358(r)-5.00129( )-184.573(m)17.4977(o)-7.00239(d)-7.00239(e)-2.64358(l)0.356603(i)0.356603(n)]TJ [(W)-9.64597(H)-2.28698(A)9.78449(5)-7.00239(8)-7.00239(. 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